What is degenerative motor neuropathy, and how does it differ from ALS?

Degenerative neuropathies are nerve disorders in which motor and sensory nerves degenerate without any apparent external factors. One of the main groups of degenerative neuropathies is known as Charcot-Marie-Tooth disease (CMT). CMT can lead to progressive paralysis (paresis) and muscle wasting (myopathy) without accompanying sensory disturbances. In this scenario, it can be difficult to distinguish CMT from ALS, particularly from progressive muscular atrophy (PMA). Unlike in ALS, the paresis in CMT usually affects both legs symmetrically and progresses very slowly. The distribution pattern of the paralysis and the slow progression of the disease usually allow for a distinction between ALS and CMT. Genetic factors are known for some degenerative neuropathies, while the underlying mechanisms remain unknown for many of these peripheral nerve disorders.