Is it a good sign if the fasciculations subside?

Fasciculations in ALS result from the degeneration of motor neurons in the spinal cord and their axons, which connect to the muscles. As nerve control of the muscles declines, uncontrolled electrical discharges occur within the muscle cells, manifesting as spontaneous movements of the muscle fibers (fasciculations). As the disease progresses, muscle mass is lost (myatrophy). As muscle mass decreases, the frequency and intensity of fasciculations also decrease. Therefore, fasciculations are most commonly observed in the early stages of ALS, while this symptom diminishes as the disease progresses.